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What Are the Molecular Roots of Alzheimer’s?

By Mark Silvanic, 9:00 am on

Professors and associates at Missouri’s Washington University School of Medicine recently published a study on Alzheimer’s disease (AD) in the eLife journal. The study focuses on the genetics and molecular science behind AD. Professional caregivers from Colorado Springs Home Care Assistance want to share the key observations of this research paper in the following article.     

TREM2, which makes up a large portion of microglia cells in the brain and spinal cord, helps maintain the central nervous system by removing toxic substances. The TREM2 protein was carefully analyzed in relation to the onset of AD.

Amyloid beta is a plaque that tends to build up in the brain. Microglia cells can engulf this plaque in a process known as phagocytosis. A molecular change or mutation in TREM2 protein can have a direct impact in the performance of microglia cells and can lead to cognitive impairment.

Extensive research shows a direct link between the structure of TREM2 protein and the severity of AD. However, scientists still do not fully understand what triggers mutation in TREM2, and some experts suggest this change is due to genetics. 

To successfully treat AD, scientists need to figure out how to precisely manipulate TREM2 on a molecular scale and find ways to reduce the concentration of amyloid beta and other plaques. A combination of drugs may have to be developed to control AD.

TREM2 can also relieve inflammation in the respiratory and cardiovascular systems and shows promising results in slowing the progression of dementia and Parkinson’s disease.

Although there is no cure for Alzheimer’s at present, your loved one can benefit from a range of diet, exercise, and mental stimulation plans from Home Care Assistance. Our Cognitive Therapeutics Method is designed to slow cognitive decline in seniors and delay memory impairment. To learn more about this program or to hire licensed and experienced Alzheimer’s caregivers in Colorado Springs, give us a call at (719) 822-1229.